2024 Lexus Rx 350 Hybrid Mpg. Epa fuel economy equivalent (for hybrid and electric vehicles), combined/city/highway (mpge) Use our handy tool to get estimated annual fuel costs based on your driving habits.

37 mpg city / 34 mpg highway / 36. Research the 2024 lexus rx 350 at cars.com and find specs, pricing, mpg, safety data, photos, videos, reviews and local inventory.